Journal Description

Cancer Cell Research

Cancer Cell Research (ISSN 2161-2609) is an Cancer Cell Research is an international, peer-reviewed journal dedicated to publishing high-quality research at the intersection of artificial intelligence (AI) and cancer cell biology. The journal aims to accelerate mechanistic discovery and translational innovation by promoting rigorous AI methodologies that generate biologically interpretable and clinically relevant insights into cancer cell states, behaviors and therapeutic vulnerabilities. The journal welcomes studies that develop, validate, or apply AI and advanced computational approaches to understand cancer at the cellular and microenvironmental levels, including tumor heterogeneity, plasticity, cel-cell interactions, evolution, and treatment response. We emphasize reproducibility, transparent reporting, robust validation, encourage the sharing of code, data and benchmarks when feasible.

Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
High Visibility: indexed within CNKI, Google scholar, Changjiang Library.

Imprint Information Online ISSN: 2161-2609 About Open Access Journals

Vol. 12

NO.45 2025

Vol. 12

NO.46 2025

Vol. 12

NO.47 2025

Vol. 12

NO.48 2025

Article

SWOT Analysis of Community Elderly Health Examination Models and Health Smart Station Models in Shanghai (Optimized English Version)

by Danma Jiang, Bihua Chen, Tin Shen1, Chunyan Lu, Min Chen1, Zhigang Chen, Dengxiao Huang

Cancercellresearch 2025, 12(46), 1004-1009; https://doi.org/10.54762_ccr2025.46.1004-1009 (registering DOI) - 10 May. 2025

Abstract

With the accelerating global aging process, innovative community health service models have become a key issue in improving the health management of the elderly. Based on the "Notice on Further Improving Health Management Services for the Elderly in Shanghai" (2024) issued by the Shanghai Municipal Health Commission, this study systematically compares the strengths and weaknesses of traditional health examination models and health smart station (health kiosk) models, incorporating policy context and empirical data. [...] Read more.

Abstract: With the accelerating global aging process, innovative community health service models have become a key issue in improving the health management of the elderly. Based on the "Notice on Further Improving Health Management Services for the Elderly in Shanghai" (2024) issued by the Shanghai Municipal Health Commission, this study systematically compares the strengths and weaknesses of traditional health examination models and health smart station (health kiosk) models, incorporating policy context and empirical data. Applying the SWOT（Strength ， Weakness ，Opportunity ，Threat） analysis framework, the research finds that traditional models have significant advantages in policy implementation and resource integration but face limitations such as service homogenization and lagging informatization. The smart station model compensates for the shortcomings of traditional models with its technological advancement and service flexibility, but high operational costs and the digital divide among the elderly remain urgent issues to address. The study proposes promoting the deep integration of the two models through the construction of data-sharing platforms, family doctor collaboration mechanisms, and policy optimization. The research is presented from three perspectives: theoretical construction, practical cases, and policy recommendations, providing systematic references for health management in an aging society. Full article

(This article belongs to the Section Cancer cell Research)

Article

Progress on Chinese medicine for hair loss based on ancient Chinese medicine books

by Ying Zhang, Kai Yin, Qinghua Meng.

Cancercellresearch 2025, 12(45), 1000-1003; https://doi.org/10.54762_ccr2025.45.1000-1003 (registering DOI) - 10 May. 2025

Abstract

Objective: With the intensification of social competition and the acceleration of the pace of life, mental tension, stress and other adverse emotions directly affect the health of the human body. More and more people are experiencing different degrees of hair loss. [...] Read more.

Abstract: Objective: With the intensification of social competition and the acceleration of the pace of life, mental tension, stress and other adverse emotions directly affect the health of the human body. More and more people are experiencing different degrees of hair loss. Hair loss has a great impact on the aesthetics of the appearance, and can even cause personality deformities. The pathogenesis research of treatment on alopecia by western medicine is not clear, which has large amount of side effects, containing many drug contraindications, serious adverse reactions and poor long-term effects. People want to improve the situation of hair loss, but they are not willing to accept western medicine treatment. The traditional Chinese medicinal is a good choice to therapy the hair loss. Therefore, the research of Chinese medicine used in hair loss is a meaning project.Methods: According to the published references, the pathogenesis of alopecia has been listed out based on classical Chinese medicine books. Meanwhile, we analyzed the reason of hair loss and got the common Chinese drugs used in hair loss.Conclusion: We concluded that alopecia mainly related to deficiency of liver and kidney, blood stasis block, damp-heat accumulation and blood-heat wind dryness. We also have summarized the herbal topical treatments for hair loss as follows Platycladus orientalis, Polygonum multiflorum, Radix Rehmannia Praeparata, Ligustri Fructus lucid and Eclipta prostrate. Full article

(This article belongs to the Section Cancer cell Research)

Article

Network Pharmacology Reveals Mechanisms of Yang Jin Hua in Alleviating Osteosarcoma Pain

by Daofeng Zhang, Zongkai Xie, Binbin Liang, Huanling Xia.

Cancercellresearch 2025, 12(45), 983-991; https://doi.org/10.54762/ccr2025.45.992-999 (registering DOI) - 10 May. 2025

Abstract

Background: Yang Jin Hua (YJH), a traditional Chinese herbal formula, has demonstrated potential in pain management, particularly in alleviating pain associated with malignant tumors such as osteosarcoma. It has been recommended for clinical use in pain relief. [...] Read more.

Abstract: Background: Yang Jin Hua (YJH), a traditional Chinese herbal formula, has demonstrated potential in pain management, particularly in alleviating pain associated with malignant tumors such as osteosarcoma. It has been recommended for clinical use in pain relief.Objective: This study aimed to explore the mechanisms of action and interactions of YJH compounds in alleviating osteosarcoma pain using network pharmacology and molecular docking techniques.Methods: The active compounds in YJH were identified based on oral bioavailability and drug-likeness using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Potential target genes for these compounds were predicted via TCMSP and Swiss Target Prediction databases, and relevant target genes related to osteosarcoma pain relief were identified using the GeneCards database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation were performed using the Matescape database. A composition-target-pathway (C-T-P) network and protein protein interaction (PPI) network were constructed using Cytoscape 3.8.2 software.Results: Molecular docking confirmed the interactions between key active components of YJH and their targets. Key targets, including Ache, IL-6, IL1B, EGFR, and TNF, were identified as playing crucial roles in the pain mechanism of osteosarcoma. The primary active components—Quercetin, Kaempferol, Datuemine, and Apohyoscine—were found to bind with the protein structures 5KIR and 6LB4.Conclusion: This study provides an in-depth understanding of the molecular mechanisms underlying the pain-relieving effects of YJH in osteosarcoma, offering a theoretical basis for its application in osteosarcoma pain management and contributing to the development of alternative pain relief strategies based on traditional Chinese medicine. Full article

(This article belongs to the Section Cancer cell Research)

Article

Potential mechanism of Xuefu Zhuyu Decoction in Treating Lower Limb Venous Thrombosis based on Network Pharmacology and Molecular Docking Technology

TengyuChen

Zimeng Yi

Hongzong Si

Cancercellresearch 2024, 11(43), 958-969; https://doi.org/10.54762/ccr2024.958-952 (registering DOI) - 11 Oct. 2024

Abstract

Objective: This study aims to elucidate the mechanism of Xuefu Zhuyu decoction (XFZY) in treating lower limb venous thrombosis (LLVT) using network pharmacology and molecular docking technology. Methods: The active ingredients and corresponding targets of XFZY were determined through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, PubChem, and SwissTargetPrediction databases. LLVT-related targets were searched from the Human Gene and Online Mendelian Inheritance in Man databases. Intersection targets were subjected to protein-protein interaction (PPI) network construction using the STRING database, with core targets identified based on their betweenness. Cytoscape was used to construct a “drug-component-target” network, and major compounds were screened out according to the betweenness. Gene Ontology (GO) and Kyoto Encyclopedia of Genes Genomes (KEGG) pathways enrichment analyses were conducted using the Metascape database. Molecular docking validation was carried out using AutoDock 1.5.7. Results: A total of 154 active constituents were identified, including major compounds such as baicalin, luteolin and flavanones. PPI, GO, and KEGG highlighted key targets for LLVT, including TP53, SRC and HSP90AA1, with major signaling pathways like PI3K-Akt, MAPK, and Rap1 pathways, involving various biological processes such as cancer, cell migration and phosphorylation. Stable complexes could be formed between the active constituents of XFZY and target proteins. Conclusion: This study provides preliminary insights into the multi- component, multi-target, and multi-pathway therapeutic mechanisms of XFZY for LLVT, laying a foundation for its clinical development. Full article

(This article belongs to the Section Cancer cell Research)

Article

LncRNA regulates the progression of Triple-negative breast cancer

Cancercellresearch 2024, 11(43), 970-976; https://doi.org/10.54762/ccr2024.970-976 (registering DOI) - 11 Oct. 2024

Abstract

Managing triple negative breast cancer (TNBC) is difficult because of its unfavorable outlook, diversity, increased invasiveness, tendency to recur and spread, and absence of targeted treatment options. Recent research has found that numerous long non-coding RNAs (lncRNAs) are essential in TNBC. We examined the existing research on the impact of lncRNAs in the development, resistance to treatment, and outlook for TBNC individuals. LncRNAs act as sponges, regulating the expression of genes, miRNAs, and transcription factors related to the pathogenesis and progression of TNBC. LncRNA affects the progression of TNBC by participating in cancer stemness, EMT, regulating cell proliferation and apoptosis, participating in cell invasion and metastasis, and participating in angiogenesis regulation. In addition, lncRNAs can be used to assist in the diagnosis and prognosis evaluation of TNBC patients. Large scale research is needed on the lncRNAs to fully understand and utilize their potential as biomarkers or therapeutic targets. Full article

(This article belongs to the Section cancercellresearch)

Article

Research Progress on Mongolian Medicine Improving Tumor Microenvironment

Nominerdene Ulambayar

Cancercellresearch 2024, 11(43), 977-982; https://doi.org/10.54762/ccr2024.977-982 (registering DOI) - 16 Oct. 2024

Abstract

Mongolian medicine, rooted in centuries-old traditions, has garnered increasing attention for its potential in improving the tumor microenvironment (TME). [...] Read more.

Mongolian medicine, rooted in centuries-old traditions, has garnered increasing attention for its potential in improving the tumor microenvironment (TME). This review explores recent research progress in utilizing Mongolian medicinal practices to modulate the TME, focusing on their impact on tumor growth, metastasis, and therapeutic resistance. Key components of Mongolian medicine, including herbal remedies, dietary interventions, and therapeutic approaches such as acupuncture and moxibustion, are discussed in relation to their effects on immune responses, inflammation levels, and angiogenesis within the TME. Additionally, advancements in understanding the molecular mechanisms underlying these effects are highlighted, providing insights into potential synergies with conventional cancer therapies. By elucidating the role of Mongolian medicine in TME modulation, this review aims to contribute to the development of integrative approaches for cancer treatment and management. Full article

(This article belongs to the Section cancercellresearch)