Journals
Cancer Cell Research

Journal Description

Cancer Cell Research Vol. 12 NO.45 2025

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Article
Network Pharmacology Reveals Mechanisms of Yang Jin Hua in Alleviating Osteosarcoma Pain
by Daofeng Zhang, Zongkai Xie, Binbin Liang, Huanling Xia.
Cancercellresearch 2025, 12(45), 983-991; https://doi.org/10.54762_ccr2025.45.992-999 (registering DOI) - 10 May. 2025
Abstract
Background: Yang Jin Hua (YJH), a traditional Chinese herbal formula, has demonstrated potential in pain management, particularly in alleviating pain associated with malignant tumors such as osteosarcoma. It has been recommended for clinical use in pain relief. [...] Read more.
Abstract: Background: Yang Jin Hua (YJH), a traditional Chinese herbal formula, has demonstrated potential in pain management, particularly in alleviating pain associated with malignant tumors such as osteosarcoma. It has been recommended for clinical use in pain relief.Objective: This study aimed to explore the mechanisms of action and interactions of YJH compounds in alleviating osteosarcoma pain using network pharmacology and molecular docking techniques.Methods: The active compounds in YJH were identified based on oral bioavailability and drug-likeness using the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Potential target genes for these compounds were predicted via TCMSP and Swiss Target Prediction databases, and relevant target genes related to osteosarcoma pain relief were identified using the GeneCards database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation were performed using the Matescape database. A composition-target-pathway (C-T-P) network and protein protein interaction (PPI) network were constructed using Cytoscape 3.8.2 software.Results: Molecular docking confirmed the interactions between key active components of YJH and their targets. Key targets, including Ache, IL-6, IL1B, EGFR, and TNF, were identified as playing crucial roles in the pain mechanism of osteosarcoma. The primary active components—Quercetin, Kaempferol, Datuemine, and Apohyoscine—were found to bind with the protein structures 5KIR and 6LB4.Conclusion: This study provides an in-depth understanding of the molecular mechanisms underlying the pain-relieving effects of YJH in osteosarcoma, offering a theoretical basis for its application in osteosarcoma pain management and contributing to the development of alternative pain relief strategies based on traditional Chinese medicine. Full article
(This article belongs to the Section Cancer cell Research)
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Article
Progress on Chinese medicine for hair loss based on ancient Chinese medicine books
by Ying Zhang, Kai Yin, Qinghua Meng.
Cancercellresearch 2025, 12(45), 1000-1003; https://doi.org/10.54762_ccr2025.45.1000-1003 (registering DOI) - 10 May. 2025
Abstract
Objective: With the intensification of social competition and the acceleration of the pace of life, mental tension, stress and other adverse emotions directly affect the health of the human body. More and more people are experiencing different degrees of hair loss. [...] Read more.
Abstract: Objective: With the intensification of social competition and the acceleration of the pace of life, mental tension, stress and other adverse emotions directly affect the health of the human body. More and more people are experiencing different degrees of hair loss. Hair loss has a great impact on the aesthetics of the appearance, and can even cause personality deformities. The pathogenesis research of treatment on alopecia by western medicine is not clear, which has large amount of side effects, containing many drug contraindications, serious adverse reactions and poor long-term effects. People want to improve the situation of hair loss, but they are not willing to accept western medicine treatment. The traditional Chinese medicinal is a good choice to therapy the hair loss. Therefore, the research of Chinese medicine used in hair loss is a meaning project.Methods: According to the published references, the pathogenesis of alopecia has been listed out based on classical Chinese medicine books. Meanwhile, we analyzed the reason of hair loss and got the common Chinese drugs used in hair loss.Conclusion: We concluded that alopecia mainly related to deficiency of liver and kidney, blood stasis block, damp-heat accumulation and blood-heat wind dryness. We also have summarized the herbal topical treatments for hair loss as follows Platycladus orientalis, Polygonum multiflorum, Radix Rehmannia Praeparata, Ligustri Fructus lucid and Eclipta prostrate. Full article
(This article belongs to the Section Cancer cell Research)
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