Journals
Cancer Cell Research

Journal Description

Cancer Cell Research Vol. 12 NO.48 2025

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Article
GNB2 promotes breast cancer progression by increasing the expression of HSPA5 and inhibiting ferroptosis
by Yongxia Wang, Zhanting Kang, Rong Liu, Chenfei Tian, Kun Lu, Yalan Yang, Jingnan Wang, Shangqian Fan, Jiateng Zhong
Cancercellresearch 2025, 12(46), 1021-1025; https://doi.org/10.54762_ccr2025.48.1021-1025 (registering DOI) - 13 Apr. 26
Abstract
Breast cancer remains the most common malignancy in women worldwide and continues to impose a substantial burden in terms of incidence and mortality. Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation and reactive oxygen species accumulation, has emerged as an important process in tumor biology and a potential target for cancer therapy. [...] Read more.
Abstract: Breast cancer remains the most common malignancy in women worldwide and continues to impose a substantial burden in terms of incidence and mortality. Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation and reactive oxygen species accumulation, has emerged as an important process in tumor biology and a potential target for cancer therapy. G protein subunit beta 2 (GNB2) has recently been implicated in several human malignancies; however, its role in breast cancer and the underlying mechanism remain poorly defined. In this study, we investigated the expression, biological function and mechanistic relevance of GNB2 in breast cancer. Co-immunoprecipitation, qPCR, western blotting, flow cytometry and biochemical assays were used to define the role of GNB2 in breast cancer cells. GNB2 was found to be upregulated in breast cancer and to promote malignant progression. Mechanistically, GNB2 interacted with HSPA5 and suppressed ferroptosis by increasing HSPA5 expression, thereby enhancing the proliferative and migratory capacity of breast cancer cells. Together, these findings identify GNB2 as a promoter of breast cancer progression and suggest that its oncogenic effects are mediated, at least in part, through HSPA5-dependent inhibition of ferroptosis. Our study highlights the GNB2-HSPA5 axis as a biologically relevant pathway in breast cancer and a potential target for further therapeutic investigation. Full article
(This article belongs to the Section Cancer cell Research)
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Article
The Plasma Lipids on Colon Carcinoma In Situ Risk and Possible Mediators: A Two-Step Mendelian Randomization
by Xue, Mingkun
Cancercellresearch 2025, 12(48), 1026-1031; https://doi.org/10.54762_ccr2025.48.1026-1031 (registering DOI) - 13 Apr. 26
Abstract
Observational studies have reported altered plasma lipid levels in patients with in situ colorectal cancer (isCRC), but the causal relationship remains unclear. This Mendelian randomization (MR) study aimed to investigate the causal associations between 179 plasma lipid species and isCRC risk and to further assess the mediating role of circulating inflammatory proteins. We performed a two-step MR analysis using publicly available genetic datasets. Specifically, the inverse-variance weighted (IVW), MR-Egger, [...] Read more.
Abstract: Observational studies have reported altered plasma lipid levels in patients with in situ colorectal cancer (isCRC), but the causal relationship remains unclear. This Mendelian randomization (MR) study aimed to investigate the causal associations between 179 plasma lipid species and isCRC risk and to further assess the mediating role of circulating inflammatory proteins. We performed a two-step MR analysis using publicly available genetic datasets. Specifically, the inverse-variance weighted (IVW), MR-Egger, and weighted median methods were applied, together with sensitivity analyses and instrumental variable strength assessments to ensure robustness. We found that seven lipids, including Ceramide (d42:2) and Triacylglycerol (51:1), were inversely associated with isCRC risk, whereas Phosphatidylcholine (18:0_22:6) was positively associated with risk. Mediation analysis further suggested that the inflammatory protein Fractalkine mediated approximately 8.98% of the effect of Triacylglycerol (51:1) on isCRC risk. Taken together, these findings support a causal role for specific plasma lipids in isCRC and suggest that part of this effect may be mediated through inflammatory pathways. This study highlights a potential mechanistic link and identifies promising targets for preventive strategies. Full article
(This article belongs to the Section Cancer cell Research)
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Article
Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancer
by Tingting Zhao, Zhe Zhang, Zhuo Chen, Guozheng Xu, Yongxi Wang, Fang Wang
Cancercellresearch 2025, 12(48), 1032-1041; https://doi.org/10.54762_ccr2025.46.1032-1041 (registering DOI) - 13 Apr. 26
Abstract
m5C (5-methylcytosine) is an important epigenetic RNA modification involved in the post-transcriptional regulation of gene expression and in a wide range of biological processes, including cellular metabolism, growth, apoptosis, and tumorigenesis. By affecting tumor-cell proliferation, migration, invasion, and drug sensitivity, [...] Read more.
Abstract: m5C (5-methylcytosine) is an important epigenetic RNA modification involved in the post-transcriptional regulation of gene expression and in a wide range of biological processes, including cellular metabolism, growth, apoptosis, and tumorigenesis. By affecting tumor-cell proliferation, migration, invasion, and drug sensitivity, m5C modification plays a critical role in tumor initiation and progression and is closely associated with poor prognosis in several cancers. According to their functions, m5C regulators can be classified into three groups: m5C methyltransferases (writers), m5C demethylases (erasers), and m5C-binding proteins (readers). In this review, we summarize several commonly used methods for detecting m5C methylation and discuss the molecular structures and biological functions of the m5C readers ALYREF, YBX1, YBX2, RAD52, YTHDF2, FMRP, and SRSF2. We further outline their roles and regulatory mechanisms in human cancer and highlight potential targets and perspectives for tumor therapy. Full article
(This article belongs to the Section Cancer cell Research)
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